Engineering stability, longevity, and miscibility of microtubule-based active fluids

Citation:

Chandrakar P, Berezney J, Lemma B, Hishamunda B, Berry A, Wu K-T, Subramanian R, Chung J, Needleman D, Gelles J, et al. Engineering stability, longevity, and miscibility of microtubule-based active fluids. Soft Matter. 2022.
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Abstract:

Microtubule-based active matter provides insight into the self-organization of motile interacting constituents. We describe several formulations of microtubule-based 3D active isotropic fluids. Dynamics of these fluids is powered by three types of kinesin motors: a processive motor, a nonprocessive motor, and a motor which is permanently linked to a microtubule backbone. Another modification uses a specific microtubule crosslinker to induce bundle formation instead of a nonspecific polymer depletant. In comparison to the already established system, each formulation exhibits distinct properties. These developments reveal the temporal stability of microtubule-based active fluids while extending their reach and the applicability