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The Needleman Lab
Northwest Lab Building 359
52 Oxford Street Cambridge MA 02138
Nurgaliev D, Gatanov T, Needleman DJ
Automated identification of microtubules in cellular electron tomography
. Methods in cell biology. 2010;97 :475–495.
Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T
Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules
. Molecular biology of the cell. 2010;21 :323–333.
Choi MC, Raviv U, Miller HP, Gaylord MR, Kiris E, Ventimiglia D, Needleman DJ, Kim MW, Wilson L, Feinstein SC, et al.
Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study
. Biophysical journal. 2009;97 :519–527.
Cellular allometry: the spindle in development and inheritance
. Current Biology. 2009;19 :R846–R847.
Schier AF, Needleman D
Developmental biology: Rise of the source–sink model
. Nature. 2009;461 :480–481.
Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ
How does a millimeter-sized cell find its center?
. Cell cycle. 2009;8 :1115–1121.
Needleman DJ, Xu Y, Mitchison TJ
Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy
. Biophysical journal. 2009;96 :5050–5059.
Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED
Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules
. Current Biology. 2009;19 :287–296.
Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ
Evidence for an upper limit to mitotic spindle length
. Current Biology. 2008;18 :1256–1261.
Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ
A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly
. Journal of cell science. 2008;121 :2293–2300.
Plasmid segregation: is a total understanding within reach?
. Current Biology. 2008;18 :R212–R214.
Raviv U, Needleman DJ, Ewert KK, Safinya CR
Hierarchical bionanotubes formed by the self assembly of microtubules with cationic membranes or polypeptides
. Journal of Applied Crystallography. 2007;40 :s83–s87.
Raviv U, Nguyen T, Ghafouri R, Needleman DJ, Li Y, Miller HP, Wilson L, Bruinsma RF, Safinya CR
Microtubule protofilament number is modulated in a stepwise fashion by the charge density of an enveloping layer
. Biophysical journal. 2007;92 :278–287.
Safinya CR, Ewert K, Ahmad A, Evans HM, Raviv U, Needleman DJ, Lin AJ, Slack NL, George C, Samuel CE
Cationic liposome–DNA complexes: from liquid crystal science to gene delivery applications
. Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and Engineering Sciences. 2006;364 :2573–2596.
Raviv U, Needleman DJ, Safinya CR
Cationic membranes complexed with oppositely charged microtubules: hierarchical self-assembly leading to bio-nanotubes
. Journal of Physics: Condensed Matter. 2006;18 :S1271.
Raviv U, Needleman DJ, Li Y, Miller HP, Wilson L, Safinya CR
Cationic liposome–microtubule complexes: Pathways to the formation of two-state lipid–protein nanotubes with open or closed ends
. Proceedings of the National Academy of Sciences of the United States of America. 2005;102 :11167–11172.
Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Miller HP, Wilson L, Safinya CR
Radial compression of microtubules and the mechanism of action of taxol and associated proteins
. Biophysical journal. 2005;89 :3410–3423.
Needleman DJ, Jones JB, Raviv U, Ojeda-Lopez MA, Miller HP, Li Y, Wilson L, Safinya CR
Supramolecular assembly of biological molecules purified from bovine nerve cells: from microtubule bundles and necklaces to neurofilament networks
. Journal of Physics: Condensed Matter. 2005;17 :S3225.
Needleman DJ, Ojeda-Lopez MA, Raviv U, Miller HP, Wilson L, Safinya CR
Higher-order assembly of microtubules by counterions: From hexagonal bundles to living necklaces
. Proceedings of the National Academy of Sciences of the United States of America. 2004;101 :16099–16103.
Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Jones JB, Miller HP, Wilson L, Safinya CR
Synchrotron X-ray diffraction study of microtubules buckling and bundling under osmotic stress: a probe of interprotofilament interactions
. Physical review letters. 2004;93 :198104.
Metabolic imaging via fluorescence lifetime imaging microscopy for egg and embryo assessment
From cytoskeletal assemblies to living materials
Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments
The Physics of the Metaphase Spindle.
Measuring and modeling polymer concentration profiles near spindle boundaries argues that spindle microtubules regulate their own nucleation
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