Publications

2009
Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Current Biology. 2009;19 :287–296. Download Paper
2008
Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Current Biology. 2008;18 :1256–1261. Download Paper
Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ. A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. Journal of cell science. 2008;121 :2293–2300. Download Paper
Needleman DJ. Plasmid segregation: is a total understanding within reach?. Current Biology. 2008;18 :R212–R214. Download Paper
2007
Raviv U, Needleman DJ, Ewert KK, Safinya CR. Hierarchical bionanotubes formed by the self assembly of microtubules with cationic membranes or polypeptides. Journal of Applied Crystallography. 2007;40 :s83–s87. Download Paper
Raviv U, Nguyen T, Ghafouri R, Needleman DJ, Li Y, Miller HP, Wilson L, Bruinsma RF, Safinya CR. Microtubule protofilament number is modulated in a stepwise fashion by the charge density of an enveloping layer. Biophysical journal. 2007;92 :278–287. Download Paper
2006
Safinya CR, Ewert K, Ahmad A, Evans HM, Raviv U, Needleman DJ, Lin AJ, Slack NL, George C, Samuel CE. Cationic liposome–DNA complexes: from liquid crystal science to gene delivery applications. Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and Engineering Sciences. 2006;364 :2573–2596. Download Paper
Raviv U, Needleman DJ, Safinya CR. Cationic membranes complexed with oppositely charged microtubules: hierarchical self-assembly leading to bio-nanotubes. Journal of Physics: Condensed Matter. 2006;18 :S1271. Download Paper
2005
Raviv U, Needleman DJ, Li Y, Miller HP, Wilson L, Safinya CR. Cationic liposome–microtubule complexes: Pathways to the formation of two-state lipid–protein nanotubes with open or closed ends. Proceedings of the National Academy of Sciences of the United States of America. 2005;102 :11167–11172. Download Paper
Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Miller HP, Wilson L, Safinya CR. Radial compression of microtubules and the mechanism of action of taxol and associated proteins. Biophysical journal. 2005;89 :3410–3423. Download Paper
Needleman DJ, Jones JB, Raviv U, Ojeda-Lopez MA, Miller HP, Li Y, Wilson L, Safinya CR. Supramolecular assembly of biological molecules purified from bovine nerve cells: from microtubule bundles and necklaces to neurofilament networks. Journal of Physics: Condensed Matter. 2005;17 :S3225. Download Paper
2004
Needleman DJ, Ojeda-Lopez MA, Raviv U, Miller HP, Wilson L, Safinya CR. Higher-order assembly of microtubules by counterions: From hexagonal bundles to living necklaces. Proceedings of the National Academy of Sciences of the United States of America. 2004;101 :16099–16103. Download Paper
Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Jones JB, Miller HP, Wilson L, Safinya CR. Synchrotron X-ray diffraction study of microtubules buckling and bundling under osmotic stress: a probe of interprotofilament interactions. Physical review letters. 2004;93 :198104. Download Paper
Fygenson KD, Needleman DJ, Sneppen K. Variability-based sequence alignment identifies residues responsible for functional differences in $\alpha$ and $\beta$ tubulin. Protein science. 2004;13 :25–31. Download Paper
2001
Needleman DJ, Tiesinga PHE, Sejnowski TJ. Collective enhancement of precision in networks of coupled oscillators. Physica D: Nonlinear Phenomena. 2001;155 :324–336. Download Paper

Pages